| abstract |
The present invention relates to amino alcohol derivativesnor phosphonic acid derivatives having excellentnimmunosuppressive activity, pharmacologically acceptable saltsnthereof or pharmacologically acceptable esters thereof, and tonpharmaceutical compositions comprising said compounds as annactive ingredient:n n[wherein, n R 1 and R 2 each represent a hydrogen atom, or a protectingngroup of the amino group; n R 3 represents a hydrogen atom, or a protecting group of thenhydroxyl group; n R 4 represents a lower alkyl group; n n represents an integer of from 1 to 6; n X represents an oxygen atom or a nitrogen atomnunsubstituted or substituted with a lower alkyl group or thenlike; n Y represents an ethylene group; n Z represents a C 1 -C 10 alkylene group; n R 5 represents an aryl group, or an aryl group substitutednwith substituents; n R 6 and R 7 each represents a hydrogen atom;nprovided that when R 5 represents a hydrogen atom, then Znrepresents a group other than a single bond or a straightnchain C 1 -C 10 alkylene group] . |