| abstract |
Novel calcium phosphate core particles, methods of making them, and methods ofnusing them as vaccine adjuvants, as cores, as carriers of biologically active material, and asncontrolled release matrices for biologically active material are disclosed. The core particlesnmay have a surface modifying agent and/or biologically active material, such as antigenicnmaterial or natural immunoenhancing factor, polynucleotide material, or therapeutic proteinsnor peptides, partially coating the particle or impregnated therein. The core particles have andiameter between about 300 nm and about 4000 nm, more particularly between about 300 nmnand about 2000 nm, and even more particularly between about 300 nm and about 1000 nm,nare substantially spherical in shape, and have a substantially smooth surface |