http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1469310-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92d71a3e23389a3bca747290fc6464cf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-686 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9125 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40 |
| filingDate | 2002-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcb06269e71afbe0291f34948c66d2d7 |
| publicationDate | 2011-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1469310-B1 |
| titleOfInvention | Diagnostic for scleroderma |
| abstract | Antibodies against RNA polymerase (RNAP) are frequently detected in patients suffering from diffuse scleroderma showing the rapid progress of sclerema and relate to a disease type accompanied by sclerodermatous renal crisis as a complication and showing extremely poor prognosis. Thus, it is intended to provide a method of conveniently detecting anti-RNAP antibodies which are highly useful in diagnosing scleroderma, classifying disease types and presuming organ disorders, in particular, sclerodermatous renal crisis. To identify an epitope recognized commonly by anti-RNAP antibodies, the full-length RPC62 and a fragment of RPC155, which are 2 subunits of RNAPIII of 62 kDa and 155 kDa respectively, are expressed as a recombinant protein in Escherichia coli. Then the reactivities with anti-RNAP antibody-positive and negative patients suffering from scleroderma are examined by the immunoblotting method so as to confirm that an epitope which is recognized commonly by anti-RNAP antibodies in the sera of the patients suffering from scleroderma exists in the amino acid residues at the 891- to 1020-positions of the RPC155. |
| priorityDate | 2001-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.