http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1468993-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1bd10f13ffe612eefce244f59c10e6f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-04 |
| filingDate | 2004-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b32efec76e2bc47c26cf0ec33434e36c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47c2ffc26ff1d562789253be6ac73fc2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_203e2ed78622152676989f007be2cf9b |
| publicationDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1468993-B1 |
| titleOfInvention | Process for the preparation of hexahydropyridazine-3-carboxylic acid derivatives |
| abstract | Production of hexahydropyridazine-1,3-dicarboxylic acid derivatives (I) comprises reacting a 2,5-disubstituted carboxylic acid ester (II) with a hydrazine-1,2-dicarboxylate ester (III) in the presence of a base with a pK above 8.5 in a ketone solvent and treating the resulting hexahydropyridazine-1,2,3-tricarboxylic acid ester (IV), which is not isolated, with a basic aqueous medium. Production of hexahydropyridazine-1,3-dicarboxylic acid derivatives of formula (I) comprises reacting a 2,5-disubstituted carboxylic acid ester of formula (II) with a hydrazine-1,2-dicarboxylate ester of formula (III) in the presence of a base with a pK above 8.5 in a ketone solvent and treating the resulting hexahydropyridazine-1,2,3-tricarboxylic acid ester (IV), which is not isolated, with a basic aqueous medium: [Image] R3>-CH2-CH2-CH2-CH(R3>)-C(O)OR2> (II) RO(O)C-NH-NH-C(O)OR (III) R : (un)saturated alkyl, aralkyl or aryl, all optionally substituted; R2>optionally substituted alkyl; and R3>halo or a nucleofuge organic group. |
| priorityDate | 2003-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.