http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1468684-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f4c2477bdea308bc9dec3feded37457 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-32 |
| filingDate | 2003-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b398c2210bb006776d1c19b6d492f35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b785bd347033ce95bd44574bced38a33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3fee2b2a16389ac8b4da8082a7382bc |
| publicationDate | 2004-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1468684-A1 |
| titleOfInvention | Sigma receptor binder containing indanone derivative |
| abstract | The present invention provides an indanone derivativenand an excellent sigma receptor binding agent comprising annindanone derivative. More specifically, it provides ansigma receptor binding agent comprising an indanonenderivative represented by the following formula, anpharmacologically acceptable salt thereof or a hydrate ofnthem.n nIn the formula (I), R 1 , R 2 , R 3 and R 4 are the same as orndifferent from each other and each represents hydrogen atom,na halogen atom, hydroxyl group, nitrile group, a C 1-6 alkylngroup which may be substituted, a cycloalkyl group havingnthree to eight carbon atoms which may be substituted, a C 1-6 nalkoxy group which may be substituted, a cycloalkoxy groupnhaving three to eight carbon atoms which may be substituted,nan acyl group having one to six carbon atoms which may bensubstituted, a C 1-6 alkoxycarbonyl group which may bensubstituted, a C 1-6 alkylaminocarbonyloxy group which may bensubstituted, a di(C 1-6 alkyl)aminocarbonyloxy group whichnmay be substituted, nitro group, an amino group which maynbe substituted, an amido group which may be substituted,nmercapto group or a thio-C 1-6 alkoxy group which may be nsubstituted, and further R 1 with R 2 , R 2 with R 3 , or R 3 withnR 4 may together form an aliphatic ring, an aromatic ring, anheterocyclic ring or an alkylenedioxy ring; the partialnstructure:n nrepresents a group represented by >CH-CH 2 -, >C=CH- orn>C(-R 7 )-CH 2 -; m represents an integer of 0 or 1 to 5; and R 5 nrepresents hydrogen atom, a C 1-6 alkyl group which may bensubstituted, a C 2-6 alkenyl group which may be substituted,na C 2-6 alkynyl group which may be substituted, a cycloalkylngroup having three to eight carbon atoms which may bensubstituted, a 2,2-(alkylenedioxy)ethyl group or a groupnrepresented by the formula:n n(wherein the ring C represents benzene ring, an aliphaticnring or a heterocyclic ring; R 6 s are the same as orndifferent from each other and each represents hydrogen atom,na halogen atom, hydroxyl group, nitrile group, a C 1-6 alkylngroup which may be substituted, a C 2-6 alkenyl group whichnmay be substituted, a C 2-6 alkynyl group which may bensubstituted, a cycloalkyl group having three to eightncarbon atoms which may be substituted, a C 1-6 alkoxy groupnwhich may be substituted, a C 1-6 alkoxyalkoxy group which nmay be substituted, an aryloxy group which may bensubstituted or an aralkyloxy group which may be substituted,nand further two of R 6 s may together form an aliphatic ring,nan aromatic ring, a heterocyclic ring or an alkylenedioxynring; R 7 represents a halogen atom, hydroxyl group, a C 1-6 nalkyl group which may be substituted, a C 1-6 alkoxy group,nnitrile group, a halogeno-C 1-6 alkyl group, a hydroxyl-C 1-6 nalkyl group, a cyano-C 1-6 alkyl group, an amino-C 1-6 alkylngroup, nitro group, azide group, an amino group which maynbe substituted, a carbamoyl group which may be substituted,na carboxyl group which may be substituted, mercapto groupnor a thio-C 1-6 alkoxy group; and n represents an integer ofn1 to 5), provided that 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine,na pharmacologicallynacceptable salt thereof or a hydrate of them are excluded. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8580822-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1779867-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1779867-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3680237-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014008629-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8247563-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104520272-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104520272-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10682358-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2114166-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10172866-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015038350-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105121408-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2114166-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3044223-A4 |
| priorityDate | 2002-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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