abstract |
Compounds of formula (1) wherein m is 0, 1 or 2; wherein when m is 0, Z is 0;nwhen m is 1, Z is N, and when m is 2, Z is C; Y is H, OH, NH 2 , or an organic moiety of 1-20C,noptionally additionally containing 1-8 heteroatoms selected from the group consistingnofN, P, O, S and halo; each 1 1 and 1 2 is independently 0-5; 1 3 is 0 or 1; each of R 1 , R 2 andnR 3 is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containingn1-4 heteroatoms selected from the group consisting of halo, N, P, O and S or each of R 1 nand R 2 may independently be halo, COOR, CONR 2 , CF 3 , CN or NO 2 , wherein R is H ornlower alkyl (1-4C) or alkyl (1-6C); n is 0 or 1; X is a linker; with the proviso that Y is not antropolone, a coumarin, or an antioxidant containing an aromatic group and with the furthernproviso that if 1 3 is 0, neither R 1 nor R 2 can represent F in the para position; and are usefulnas calcium channel blockers. Libraries of these compounds can also be used to identifynantagonists for other targets. |