| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6dccce985b8ab853026e48bca18ac56f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-194
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-44 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate |
1996-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5901cee47ba9a4c377f31ccc1a4c11c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ea9e73b07d11cff4d6ea62ea48bd43a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b0566c8e9d2bba6700d4bd1706e4e0f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5266c7f12615940b4e5443d89c5233ac |
| publicationDate |
2004-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1464337-A1 |
| titleOfInvention |
Regulation of intracellular glucocorticoid concentrations |
| abstract |
The interconversion of inactive 11-keto steroids with their active 11β-hydroxynequivalents can be controlled by the use of inhibitors of the 11β-reductase enzyme,nsuch as carbenoxolone (3β-(3-carboxypropionyloxy)-11-oxo-olean-2-en30-oic acid).nSuch inhibitors may be put to a number of therapeutic uses in humans and animals,nfor instance to inhibit hepatic gluconeogenesis, to lower intracellular cortisolnconcentration, to increase insulin sensitivity in adipose tissue and muscle, and tonprevent or reduce neuronal loss/cognitive impaiment due to glucocorticoid potentiatednneurotoxicity or neural dysfunction or damage. |
| priorityDate |
1995-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |