| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e1018b924ad1e238642eaad9d2172a7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-465 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-4625
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N24-08 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-465 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N24-08 |
| filingDate |
2003-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8de025b65d31727a3a7352df1c1d48cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afdc1e341803f8e15be25dbdec460f80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6efdeea2d8204bd36700912eae591d3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_887e3f880f913c59f2c68e9ce951cd8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30a759c480d3fdfe8916b94410daadb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12c63e576c23c4554b515383f1645adf |
| publicationDate |
2004-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1463952-A2 |
| titleOfInvention |
Quantitative ranking of transient ligand binding to target biomolecules |
| abstract |
The present invention relates to a new use of NMR for quantitatively ranking transient ligand binding to target biomolecules. The present invention also relates to a new method to identify ligand site obeying two-state and more complex binding behavior in a transient complex of a ligand with a target molecule, still with the use of NMR. There is also provided an efficient method to quantitate fast dissociation rates of ligands containing at least one magnetic nuclei by performing NMR relaxation dispersion experiments at different protein concentrations, enabling the evaluation of populations and exchange rates, and extending the practical applicability of the NMR relaxation dispersion experiments. |
| priorityDate |
2002-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |