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filingDate 2003-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2004-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1463760-A2
titleOfInvention Common lymphatic endothelial and vascular endothelial receptor-1 (clever-1) and uses thereof
abstract A novel protein Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 (CLEVER-1) is described. CLEVER-1 mediates leukocyte and malignant cell binding to vascular and lymphoid endothelial cells. CLEVER-1 is the first protein that has been reported to mediate both influx into and efflux from the lymph nodes. Also provided are methods of treating inflammation and preventing metastasis of malignant cells by providing an inhibitor of CLEVER-1 binding.
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