| abstract |
Compounds of formula (I) and salts or solvates thereof are disclosedn wherein Y is CR 1 and V is N; or Y is CR 1 and V is CR 2 ; R 1 represents CH 3 SO 2 CH 2 CH 2 NHCH 2 -Ar-, wherein Ar is furan or thiazole, each of which may optionally be substituted by one or two halo, C 1-4 alkyl or C 1-4 alkoxy groups; R 2 is hydrogen C 1-4 alkoxy or halo; R 3 is benzyl, halo-, dihalo- or trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- or trihalobenzyloxy or benzenesulphonyl; R 4 is halo or C 1-4 alkoxy or is not present; nand wherein either (a) R 3 represents 3-fluorobenzyloxy; and/or (b) R 4 is halo and is substituted in the 3-position of the phenyl ring; nand wherein halo represents fluoro, chloro or bromo. n Processes for the preparation of the compounds, pharmaceutical formulations of the compounds, the use of the compounds in therapy, and methods of treatment of inter alia cancer and malignant tumours by administration of the compounds is also disclosed. |