| abstract |
The inventive pharmaceutical composition having thrombolytic anti-inflammatory and cytoprotective properties comprises active proteases attached to a gel or the mixture of gel and a water-soluble polymer. Said attachment is carried out with the aid of radiation, preferably gamma-radiation or accelerated electrons. Said composition also contains proteases which are stable at a temperature up to 70 °C, preferably at a temperature ranging from 30 to 40 °C, such as subtilisin, chymotripsin, papayotin or streptokinase. Polyethylene, dextrane or polyglicane gels are preferably used as a gel. The water-soluble polymer is embodied in the form of polyethylenglicol, polyvinyl alcohol, dextrane or polyglycan. The method for producing and using said composition is also disclosed. The inventive composition can be widely used for cardiology, nephrology, surgery rheumatology, gynecology and gastroenterology. |