| abstract |
Compounds having formula (I), wherein R3 is selected from H, OH and NH¿2; R?30 is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)¿2?-; or W may be -CH2- if X is -C(=O)-; X is selected from -CH2-, -N(R?4¿)-, and -O-, except that when W is -CH¿2?-, X is -C(=O)-; Y is a bond or -C(R?40)(R45¿)-; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and R?1, R2, R24 and R25¿ are as defined in the specification. |