abstract |
The present invention is to efficiently and simplynprepare an optically active 7-substituted-2-aminotetralinnwith industrial advantage. n In the process, a 7-substituted-2-tetralone or itsnbisulfite adduct is reduced with a microorganism to annoptically active 7-substituted-2-tetralol. Then, a sulfonylngroup is introduced to the hydroxy group to form annoptically active 7-substituted-2-sulfonyloxytetralin. Then,nwith inversion of the configuration, a nitrogen substituentnis introduced using a nitrogen nucleophile to form annoptically active 2,7-substituted tetralin. Furthermore, ifnnecessary, the nitrogen substituent is converted into a non-substitutednamino group. Thus, an optically active 7-substituted-2-aminotetralinnor its salt is prepared. |