| abstract |
The invention concerns compounds of general formula (I), wherein: D represents the group Z-HET, -HET being a heterocycle with 5 members such as oxadiazolone (II) or thiazolidine (III) corresponding to formulae (II) and (III) and Z being selected in the group consisting of -(CR1R2)n- and -(CR1=CR2)n; or D represents the group Z=HET, -Z- representing, with the heterocycle, a -Z=HET group of formula (IV) or (V), wherein: -Z= represents -CR1. Said compounds are useful as inhibitors specific of secreted non-pancreatic human phospholipase A2 (PLA2-snph) of group II, in particular for treating inflammatory pathologies . |