| abstract |
Phenylalanine derivatives of the following formula, analoguesnthereof and pharmaceutically acceptable salts thereof have annantagonistic activity to α4 integrin. They are used as therapeuticnagents or preventive agents for various diseases concerning α4 integrin innwhich α4 integrin-depending adhesion process participates in thenpathology, such as inflammatory diseases, rheumatoid arthritis,ninflammatory bowel diseases, systemic lupus erythematosus, multiplensclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes,ncardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation,ntumor metastasis and transplantation rejection.n nwherein R1 is a methyl group and R2 is a methoxy group. |