| abstract |
Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB): <CHEM> and the following general formula (IA') or (IB'): <CHEM> where the symbols are as disclosed in the specification, are provided as desired compounds. <??>These compounds have the action of selectively inhibiting PDE7, thereby increasing the intracellular cAMP level and inhibiting the activation of T cells. Thus, they are useful for prevention and treatment of various allergic diseases and inflammatory or immunological diseases. |