http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1450766-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b58f981963f6d55d627139e778c4ef7b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2002-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cc3b7748fafa256509613c11fc9fe09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e1ca2a01538e0c1043063375a4cd45f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edaa2d9015dbcb261d4185ed396b9629 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88fee9edb434a15e87d4421d381bb825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e66f992756e61551a952936f050ad681 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3267d8f2d9bc67815021e95abcacf8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be9ec432c14a561be68152ac8f4a92b7 |
| publicationDate | 2004-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1450766-A1 |
| titleOfInvention | Prolonged release biodegradable microspheres and method for preparing same |
| abstract | The invention concerns a method for preparing a pharmaceutical composition in the form of microspheres with prolonged release of a water-soluble active principle. The invention is characterized in that it comprises the following successive steps: dissolving an active principle in an appropriate amount of water; emulsifying the resulting aqueous solution of active principle with a d,l-lactid-co-glycolide matrix copolymer, of average molecular weight ranging between 40000 and 80000, dissolved in a chlorinated hydrocarbon, resulting in a first microfine and homogeneous emulsion; emulsifying said resulting first emulsion in an external aqueous phase, containing a surfactant, a viscosity-enhancing agent and an osmotic agent; extraction-evaporation of the solvent to obtain microspheres which are recuperated after filtering, washing and drying. The invention also concerns microspheres obtainable by implementing said method, having continuous release over a period of more than two months, advantageously over a period of at least three months. |
| priorityDate | 2001-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.