abstract |
The present invention relates to the single-chain thrombomodulin ("TM") andnanalogs thereof that are not susceptible to cleavage by proteases and retainnthe biological activity of thrombomodulin, as well as methods of use in, fornexample, antithrombotic therapy. Novel proteins, nucleic acid genensequences, pharmaceuticals and methods of inhibiting thrombotic activitynare disclosed. |