| abstract |
Pyrrolopyrimidine derivatives represented by thenformula:n nwherein R 3 represents a hydrogen atom or a C 1 -C 5 alkylngroup, R 4 and R 5 are identical or different, and eachnrepresents a hydrogen atom or a C 1 -C 5 alkyl group; X 4 nrepresents a hydroxyl group, a chlorine atom, a brominenatom, or an iodine atom; and X 5 represents a halogen atom,na C 1 -C 5 alkyl group, a C 1 -C 5 alkoxy group, a C 1 -C 5 nalkylthio group, a trifluormethyl group, or antrifluoromethoxy group. These pyrrolopyrimidine derivativesnare useful as intermediates for the preparation ofncarbamoyl tetrahydropyridine derivatives which arenefficacious against CRF-related diseases. |