| abstract |
The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamidenderivative represented by thengeneral formula:n nwherein R 1 is an optionally substituted lower alkyl group, annoptionally substituted lower alkoxy group, an optionallynsubstituted lower alkenyl group, a cycloalkyl group or a lowernacyl group etc.; nQ is a hydrogen atom or an optionally substituted lower alkylngroup; and nZ is a hydrogen atom or a hydroxy group etc., nor a pharmaceutically acceptable salt thereof, which exert anpotent and selective activated blood coagulation factor Xninhibitory activity and is useful as an agent for the preventionnor treatment of a disease occurred associating an activated bloodncoagulation factor X, a pharmaceutical composition comprisingnthe same and an intermediate thereof. These compounds are usefulnas preventives or remedies for various diseases such as brainninfarction, cerebral thrombosis, cerebral embolism, TIA,ncerebral vascular jerk, Alzheimer's diseases, myocardialninfarction, heart attack, heart failure, thrombosis, pulmonaryninfarction and pulmonary embolism. |