Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e0cd68c12c78f36257d166c94da870b |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-246 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0677 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0683 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39 |
filingDate |
2002-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2011-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_330aae3784ac42fed6403655225c3720 |
publicationDate |
2011-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1438395-B1 |
titleOfInvention |
Growing xenotransplant material in culture |
abstract |
Over time, cultured mammalian cells aggregate into an artificial tissue with 10% homologous serum and nicotinamide. Neonatal porcine islets alone have a SGS index of 4.6. Co-culture with neonatal porcine Sertoli cells formed free-floating islet-like structures, 300-600 microns in diameter (SGS index 21). Basal secretion of insulin remains high for islets in a heavily confluent mixed cell culture.Re-seeded cultures were very responsive to glucose (SGS index 21.8). Co-culture with fibroblasts also provides a high SGS index, permitting use of the recipient's fibroblast line as support/trophic cells for an xenotransplantable graft, as for treatment of diabetes. |
priorityDate |
2001-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |