http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1437361-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e19ed5092514d4f22acfa3bc98b8b572 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2002-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3c4e35099d636d9c86821f946159faa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27de68369ac70e32b816699a830d82f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09210d17e3591de3019e2e7af7052a14 |
| publicationDate | 2007-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1437361-B1 |
| titleOfInvention | Method of producing 17beta-(substituted)-3-oxo-delta 1,2-4-azasteroids |
| abstract | A 4-stage process is claimed for the preparation of 17beta -substituted 3-oxo-delta 1>,2-4-aza-steroids (I) from the 1,2-saturated analogs (II), via new fused hydroxy-oxazolidinedione aza-steroid derivative intermediates (IV) and new 2-substituted aza-steroid derivative intermediates (V). Preparation of 3-oxo-delta 1>,2-4-aza-steroids of formula (I) involves: (a) reacting a 1,2-saturated analog of formula (II) with oxalyl chloride; (b) reacting the obtained fused vinylidene-oxazolidinedione derivative of formula (III) with a reactant for adding hypobromous acid at the 2,3-double bond or with a trichloromethylsulfonyl halide; (c) cleaving the heterocyclic ring of the obtained fused 2-substituted 3-hydroxy-oxazolidinedione derivative of formula (IV); and (d) eliminating H-R 5from the obtained 2-substituted aza-steroid of formula (V). [Image] [Image] R 1>1-4C alkyl, OR 2>or NR 3>R 4>; R 2>1-4C alkyl; R 3>, R 4>H or 1-4C alkyl; R 5>Br or SO 2CCl 3. Independent claims are included for: (i) the preparation of (I) by steps (c) and (d) only; (ii) the intermediates (IV) and (V) as new compounds; and (iii) the preparation of (IV) by step (b) or by steps (a) and (b). ACTIVITY : None given in the source material. MECHANISM OF ACTION : Testosterone 5alpha -reductase inhibitor. |
| priorityDate | 2001-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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