| abstract |
The present invention relates to injections for ocular tissuesncontaining a conjugate covalently bonded a drug to PEG. When the drug-PEGnconjugate is injected into the ocular tissues, the drug can be retainednin the ocular tissues such as an iris, a ciliary body, a vitreous body, a retinanand an optic nerve for a long period. Accordingly, the injections for ocularntissues of the present invention make it possible to treat or prevent diseasesnin various ocular tissues over a long period by a single administration. PEGncan be any of straight-chain, stellate and branched. In the case of straight-chainnPEG, since the drugs are generally bonded using hydroxyl groups atnits both ends, a binding ratio of the drug to PEG is 1:1 or 2:1. Since stellatenand branched PEGs have plural hydroxyl groups, plural covalent bond ofndrugs to PEG can be formed. |