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filingDate 2002-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2004-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1435233-A1
titleOfInvention Cyclosporin-based pharmaceutical compositions
abstract A pharmaceutical formulation for the oralnadministration of cyclosporin is described, whichnformulation is capable of providing substantiallynconstant and foreseeable plasma levels of the activeningredient. The formulation has the following quali-quantitativencomposition by weight:n (a) cyclosporin in the amount of from about 8 to aboutn12% of the total weight; (b) ethanol in the amount of from about 12 to about 18%nof the total weight; (c) a polyoxyethylene/polyoxypropylene block copolymernin the amount of from about 8 to about 12% of the totalnweight; (d) water in the amount of from about 4 to about 6% ofnthe total weight; (e) a solubilizer having an HLB from 13 to 15 in thenamount of from about 28 to about 40% of the totalnweight; (f) an ester of a C 1 -C 6 alkyl alcohol and a C 14 -C 18 nsaturated fatty acid in the amount of from about 20 tonabout 30% of the total weight.
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