Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9c9410104fff84049bb17df9d762a53 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-688 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-334 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 |
filingDate |
2002-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2008-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51957611f7be991737826fe1f7a8a681 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5155a59c0bce923c977a9736f4ba1fb0 |
publicationDate |
2008-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1434589-B1 |
titleOfInvention |
Thioester-terminated water soluble polymers and method of modifying the n-terminus of a polypeptide therewith |
abstract |
The invention provides reagents and methods for conjugating a polymer specifically to the ≡-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the ≡-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116816-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10702574-B2 |
priorityDate |
2001-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |