| abstract |
Compounds represented by the following general formula (1), which have an effect of inhibiting IL-β production, are highly soluble in water and have a favorable oral absorbability, and medicinal compositions containing the same: (1) wherein R1 represents alkyl, alkenyl, etc.; R2 and R3 represent each hydrogen, alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl, or R2 and R3 may form together with the adjacent nitrogen atom an optionally substituted nitrogen-containing saturated heterocyclic group; X, Y and Z represent each hydrogen, alkyl, halogeno, etc.; and n is from 1 to 5. |