| abstract |
A controlled release pharmaceutical composition for oral use comprising a solid dispersion of ni) carvedilol, which at least partially is in an amorphous form, nii) a pharmaceutically acceptable polymer that has plasticizing properties and which has a melting point or melting interval of a temperature of at the most 200 °C, nand the composition being designed to release carvedilol with a substantially zero order release, The polymer is typically a polyethylene glycol and/or a polyethylene oxide having a molecular weight of at least about 20,000 in crystalline and/or amorphous form or a mixture such polymers, and the active substance is typically carvedilol. |