| abstract |
By analyzing hematopoietic stem cell proliferationnregulators produced by stroma cells, a cDNA library isnconstructed and novel hematopoiesis-associated genes arenisolated. Genes encoding the proteins as specified in thenfollowing (a) or (b): (a) having an amino acid sequencenrepresented by one of SEQ ID NOS selected from the groupnconsisting of SEQ ID NOS: 2, 4, 6, 8, 10 and 12; or (b) havingnan amino acid sequence derived from the amino acid sequencenas defined in the above (a) by deletion, substitution or additionnof one to several amino acids andhaving an activity of regulationnhematopoietic stem cell proliferation. |