| abstract |
A benzimidazole derivative of formula (1):n n(wherein R represents a hydrogen atom or a methoxy group, andnn is 0 or 1) or a salt thereof; and a medicament containingnthe same. n The compounds of the present invention, due tonminimized difference in therapeutic effect between subjects,nwhich difference would otherwise be derived from differentnCYP2C19 activity from subject to subject, ensure that allnpatients can enjoy proper therapeutic effects at the samendose of the drug. Also, the compounds of the invention havenlow risk of drug interaction caused by induction of CYP1Anfamily member enzymes, as well as low risk of development ofncancer, and thus is useful as a remedy for peptic ulcer,nreliably providing therapeutic effects with safety. |