| abstract |
This invention provides a compound represented by thenformula (I) :n n wherein R 1 is a hydrogen atom, a halogen atom, hydroxy, nitro,noptionally halogenated alkyl, alkoxy optionally havingnsubstituents, acyl or amino optionally having substituents; R 2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl,npyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl ornthiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safenpharmaceutical comprising the compound of the formula (I) , whichnhas an excellent apoptosis inhibitory effect and MIF bindingneffect, for preventing and/or treating heart disease, nervousndegenerative disease, cerebrovascular disease, central nervousninfectious disease, traumatorathy, demyelinating disease, bonenand articular disease, kidney disease, liver disease,nosteomyelodysplasia, AIDS, cancer, and the like. |