| abstract |
An optically active form of the quinazolinone derivatives representednby the general formula (1):n n[wherein Y represents a phenyl group or C2-C7 alkyl group; E representsn-CH= or nitrogen atom; and R represents a C1-C4 alkyl group and so on],nor pharmaceutically acceptable salts thereof, has a selective antagonism fornthe M3 muscarinic receptor and depressant action on the frequency ofnrhythmic bladder contractions, and it is useful for the treatment of pollakiurianand urinary incontinence. |