http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1419786-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6887 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1093 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2002-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67eb2c8460f325a56fb8b0fcc1412589 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52b0328c355fa09df67b5c2100ff63db |
| publicationDate | 2004-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1419786-A1 |
| titleOfInvention | Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof |
| abstract | The invention provides chemical conjugates between an immunoglobulinnFab fragment and molecular entities imparting diagnostic or therapeuticnutility, whereby the only sites of conjugation on the Fab fragment are onenor both of the sulfhydryl groups deriving from the selective andnquantitative reduction of the inter-chain disulfide bond of said Fabnfragment and whereby said molecular entities imparting diagnostic orntherapeutic utility have at least one free sulfhydryl-reactive group,ncharacterized in that the conjugation stoichiometric molar ratio molecularnentity to Fab fragment is in the range from 0.95 to 1.05 or in the rangenfrom 1.95 to 2.05. n The invention also provides a process for preparing said conjugates andnpharmaceutical compositions thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007128873-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005003170-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107764992-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005003170-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3745129-A4 |
| priorityDate | 2002-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.