| abstract |
New substituted 4-(phenyl-N-alkyl)-piperidine compounds of Formula 1:n nwherein X is CH; R 1 is CF 3 , OSO 2 CF 3 ,nOSO 2 CH 3 , SOR 7 , SO 2 R 7 , COR 7 , CN, OR 3 , NO 2 ,nCONHR 3 , 3-thiophene, 2-thiophene, 3-furane, 2-furane, F,nCl, Br, or I; R 2 is F, Cl, Br, I, CN, CF 3 , CH 3 , OCH 3 , OH,nand NH 2 ; R 3 and R 4 are H; R 5 nis a C 1 -C 4 alkyl, an allyl, CH 2 SCH 3 , CH 2 CH 2 OCH 3 , CH 2 CH 2 CH 2 F,nCH 2 CF 3 , 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl,nor -(CH 2 )-R 6 ; R 6 is a C 3 -C 6 cycloalkyl, 2-tetrahydrofurane, orn3-tetrahydrofurane; R 7 is a C 1 -C 3 alkyl, CF 3 , or N(R 4 ) 2 ,nand pharmaceutically acceptable salts thereof arendisclosed. n Also pharmaceutical compositions comprising thenabove compounds and methods wherein the above compoundsnare used for treatment of disorders in the centralnnervous system are disclosed. |