| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0356
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-42 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2002-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bca64c92f32ce981e2b902451b1d796
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6adad94a71eab907f8e2d0fbbf4386a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_814401f2f96773e8fc8be88cc501d8cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1c6db47432fcc4d16392039c35ed951
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74ce75c1e6442c60f5cc93e7c501a9cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eba515ec89e92155c73d74ddd3019d68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1db6528f0de4d3b139b50192c1dd5be1 |
| publicationDate |
2004-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1419235-A2 |
| titleOfInvention |
Knock in transgenic mammal containing a non-functional n-terminus of kv beta 1.1 subunit |
| abstract |
This invention provides a transgenic mammal containing a defective beta 1 subunit (Kvss1) of a voltage sensitive potassium channel, where the Kvss1 subunit is unable to confer N-type inactivation of the K+ but retains the ability to co-associate with Kv1 family a- subunits and thereby enhance channel surface expression. Preferably the Kvss1.1 gene encoding Kvss1 subunit has a mutation in all or a portion of codons 1-70 of its inactivation domain. The transgenic mammal is useful as a model for psychiatric and neurological disorders to identify anxiolytic compounds and pro-cognitive functions. The invention also provides for methods for screening and evaluating test compounds for their ability to modulate Kvss1.1 activity, specifically for inactivation of a potassium channel or for co-association with a-subunits. |
| priorityDate |
2001-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |