| abstract |
This invention relates to macromolecule modifiers containing biologically active drugs/biomolecules, or precursors thereof, and fluoroligomers; compositions comprising the macromolecules containing the drugs and fluoroligomers in admixture with polymers, particularly biomedical polymers; articles made from the admixtures, particularly medical devices. Specifically, the modifier has the general formulais a central portion comprising an oligomeric polymeric segment having a theoretical molecular weight of less than 15,000, and being compatible with said base polymer; wherein[oligo] is a first oligomeric segment;[link A] is a second coupling segment linking one [oligo] to another [oligo] within said central portion;n is 0 to 20;[fluoro] is a polyfluoro oligomeric group; and[link B] is a first coupling segment linking said central portion to said [fluoro] through said first coupling segment; and coupled to a bioactive moiety [Bio] or precursor thereof; andm is 1 to 20. |