| abstract |
The present invention provides a method for screening a substancenhaving a thermogenesis enhancing effect containing a compound having anneffect activating PPAR δ, an agent containing the compound, and an agentnhaving antidiabetic, antiobestic or visceral accumulated fat-loweringnfunction. n The present invention provides an agent containing a compoundnhaving an effect activating PPAR δ, which is a peroxisome proliferatornactivated receptor, and having effects which enhances nonshiveringnthermogenesis (nST), specifically enhances uncoupling respiration innmitochondria of cells in an adipose tissue or the like, or proton leak in innernmembranes of mitochondria, and increases the amount of expression ofnUCP1, and provides an antidiabetic agent, an antiobestic gent and a visceralnaccumulated fat-lowering agent containing the compound. Further, thenpresent invention provides a method for screening the compound bynmeasuring a PPAR δ activating effect. |