http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1415985-A4

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead
classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-32
filingDate 2002-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24dc3bd606917e275c737b55f197d00f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e5ca600c4959b9f2df2dedf0dc321f1
publicationDate 2005-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1415985-A4
titleOfInvention PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE AZETIDINE-2-CARBOXYLIC ACID
abstract A process for efficiently, easily, and industrially advantageously producing an optically active azetidine-2- carboxylic acid which is important as a material for medicines. The process comprises halogenating an optically active N-protected 4-amino-2-hydroxybutyric acid while inverting the configuration to form an optically active N-protected 4-amino-2-halogenobutyryl halide, subsequently subjecting the halide to hydrolysis and elimination of the amino-protecting group to form an optically active 4-amino-2-halogenobutyric acid, and then subjecting the resultant acid to cyclization and amino group protection in an alkaline aqueous solution to produce an optically active N-protected azetidine-2-carboxylic acid. Also provided is an optically active N-protected 4-amino-2-halogenobutyryl halide represented by the following formula (2), which is useful for producing an optically active azetidine-2-carboxylic acid. (2) (In the formula, P represents a group protecting the primary amino group; &ast; indicates that the carbon atom is asymmetric; and X and Y each independently represents halogeno.)
priorityDate 2001-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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