abstract |
The present invention relates to highly selective phosphodiesterase (PDE)nenzyme inhibitors and to their use in pharmaceutical articles of manufacture. Innparticular, the present invention relates to potent inhibitors of cyclic guanosinen3',5'-monophosphate specific phosphodiesterase type 5 (PDE5) that whennincorporated into a pharmaceutical product at about 1 to about 5 mg unitndosage are useful for the treatment of sexual dysfunction. |