http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1409654-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4caa011812539b15e60e081c80d49df |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-918 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-915 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-729 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-896 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 2000-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d3f29d811aecd78eb3a68aaf5bf7618 |
| publicationDate | 2004-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1409654-A1 |
| titleOfInvention | Immunological control of beta-amyloid levels in vivo |
| abstract | The present invention provides an antibody which catalyzes hydrolysis of β-amyloid at a predetermined amide linkage. The antibody preferentially binds a transition state analog which mimics the transition state adopted by β-amyloid during hydrolysis at a predetermined amide linkage. Specific antibodies provided include those which catalyze the hydrolysis at the amyloid linkages between residues 39 and 40, 40 and 41, and 41 and 42 of β-amyloid. The present antibody also provides a vectorized antibody which is characterized by the ability to cross the blood brain barrier and also catalyze the hydrolysis of β-amyloid. Also provided are methods for sequestering free β-amyloid in the blood stream, for reducing levels of β-amyloid in the brain, for reducing the level of circulating β-amyloid, for preventing the formation of amyloid plaques in the rain and for disaggregating amyloid plaques. Finally, this invention also provides a method of generating antibodies by immunizing an animal with antigen comprised of an epitope which has a statine analog or which utilizes reduced peptide bond analogs to mimic the conformation of a hydrolysis transition state of a polypeptide. |
| priorityDate | 1999-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 283.