| abstract |
There are provided compositions and preparation methods for bioavailable oral aceclofenac dosage forms. More particularly, the compositions containing water-insoluble aceclofenac, a polymeric base selected from the group consisting of polyvinyl, methyl cellulose, ethyl cellulose, hydroxypropylmethylcellulose, carboxy methyl cellulose, glyceryl monostearate, carbamer, and poloxamer, and surfactant. The compositions of the present invention can be formulated into compressed particles, granules, tablets, capsules or even semisolid preparations, which significantly increase the bioavilablity due to the improvement of dissolution of the drug in gastrointestinal tract, and reduce the manufacturing cost by simple process. |