abstract |
The present invention relates to a monoclonal antibody which specificallynreacts with natural MT4-MMP or solubilized MT4-MMP. Also, the present inventionnprovides a monoclonal antibody which specifically and efficiently recognizes a naturalnMT4-MMP catalytic domain; a human chimeric antibody, a CDR-grafted antibody, ansingle chain antibody and a disulfide stabilized antibody, comprising the same; and anmethod for detecting and determining MT4-MMP protein using the antibodies.nFurthermore, the present invention provides a diagnostic method, a diagnostic agent andna therapeutic agent for various diseases relating to MP4-MMP such as inflammation andncancer, using the antibodies. |