| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f608437b78674d77bd371f635a364d56 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525 |
| filingDate |
1996-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce8dda36dd60bb937d6c5d419de39c15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b2b600dec4b29133799ae79c7fb835c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b954a4df5b5b923512808419a3a47207 |
| publicationDate |
2004-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1407781-A1 |
| titleOfInvention |
Anti-lymphotoxin-beta receptor antibodies as anti-tumor agents |
| abstract |
This invention relates to compositions and methods useful for activating LT-β receptornsignalling, which in turn elicits potent anti-proliferative effects on tumor cells. Morenparticularly, this invention relates to lymphotoxin heteromeric complexes formed betweennlymphotoxin-α and multiple subunits of lymphotoxin-β, which induce cytotoxic effects onntumor cells in the presence of lymphotoxin-β receptor activating agents. Also within the scopenof this invention are antibodies directed against the lymphotoxin-β receptor which act asnlymphotoxin-β receptor activating agents alone or in combination with other lymphotoxin-βnreceptor activating agents either in the presence or absence of lymphotoxin-α/β complexes. Anscreening method for selecting such antibodies is provided. This invention also relates toncompositions and methods using cross-linked anti-lymphotoxin-β receptor antibodies eithernalone or in the presence of other lymphotoxin-β receptor activating agents to potentiate tumorncell cytotoxicity. |
| priorityDate |
1995-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |