| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3658808b82c59b5c52696ca74f1f7de9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 |
| filingDate |
2002-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeaf4a57f1159244e3c88dae8a0414e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fa4627a9716171c543ef196c2b77c9e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90f9f698e79aeffbce8cae9d4b96af43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7731f2893c85391d629e4b685b0bea20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b3a9d9008107689e784354a5cc2ff99 |
| publicationDate |
2004-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1405910-A1 |
| titleOfInvention |
Process for producing human thrombin by gene modification technique |
| abstract |
Producing human thrombin using a gene modification technique comprising culturing a transformant, conversion of the recovered human prethrombin into human thrombin after activation by treatment with ecarin, and purifying human thrombin from the reaction mixture, is new. Producing human thrombin with use of a gene modification technique comprises: (a) culturing a transformant constructed by transforming an animal cell with an expression vector carrying a gene that encodes prethrombin integrated into the downstream of a promoter and accumulating the thus produced prethrombin in the cell culture medium for collection; (b) conversion of the recovered human prethrombin into human thrombin after activation by treatment with ecarin; and (c) purifying such human thrombin from the reaction mixture. ACTIVITY : Hemostatic. No biological data given. MECHANISM OF ACTION : None given. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8304224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2179038-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7842477-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8697440-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2008275828-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009008821-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8206967-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7989193-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2179038-A4 |
| priorityDate |
2001-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |