| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_755f0e063405a160b3444126780baba9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-43 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-00 |
| filingDate |
2002-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c212d99fcecd9c476b10677b57d55c75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0523e8b564e8ecc56e34dca6de6a32ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e78a97c6ce3bcedde6ce8cd2183a059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dc975a7b9a35acfce4685c2bb8b4580 |
| publicationDate |
2004-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1401815-A1 |
| titleOfInvention |
Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-alpha,alpha-dimethylphenyl acetic acid |
| abstract |
This invention relates to a novel process to obtain hoghly pure 4-(cyclopropylcarbonyl)-α,α-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-α,$g)a)-dimethylphenylacetic acid of Formula II is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic. |
| priorityDate |
2001-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |