| abstract |
The present invention provides glucopyranosyloxypyrazolenderivatives represented by the general formula:n nwherein R 1 is a hydrogen atom or a hydroxyalkyl group; one ofnQ and T is a group represented by the general formula;n nthe other is an optionally substituted alkyl group or ancycloalkyl group; and R 2 is a halogen atom, a hydroxy group,nan optionally substituted alkyl group, an optionallynsubstituted alkoxy group, an alkylthio group, a group of thengeneral formula: -A-R 3 wherein A is a single bond, an oxygennatom, a methylene group, an ethylene group, -OCH 2 - or -CH 2 O-;nand R 3 is a cycloalkyl group, a heterocycloalkyl group, annoptionally substituted aryl group, an optionally substitutedntiazolyl group or an optionally substituted pyridyl group,npharmaceutically acceptable salts thereof or prodrugs thereof,nwhich exert an excellent inhibitory activity in human SGLT1,nand therefore are useful as drugs for the prevention or treatmentnof a disease associated with hyperglycemia such as diabetes,ndiabetic complications or obesity, pharmaceutical compositions ncomprising the same, pharmaceutical uses thereof and productionnintermediates thereof. |