| abstract |
A piperazine compound represented by formula (1): <CHEM> wherein X is -CH2-, -C(O)- or -CH(CH3)-; R<1> is a hydrogen atom or alkyl group; and R<2> is a hydrogen atom, alkyl group, hydroxyalkyl group, arylalkyl group, heteroarylalkyl group, carboxyalkyl group, carboxamidoalkyl group, aminoalkyl group or guanidinoalkyl group; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation. |