| abstract |
The present invention provides method of treatment of elevatednplasma homocysteine in a human or animal subject which methodncomprises administering to the subject an effective amount of antruncated cystathionine beta-synthase (CBS). The fragment maynbe one which lacks haem as a co-factor, does not require S-adenosylnmethionine for activation while being active in humannplasma. Such fragments include amino acids 40-413 of SEQ IDnNO:2 and a novel fragment thereof being amino acids 73-414 ofnSEQ ID NO:2. |