abstract |
This invention described an ICE inhibitor prodrug (I) having good bioavailability. Compoundnof formula (I) is useful for treating IL-1 mediated diseases such as rheumatoid arthritis,ninflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis,nseptic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis,nasthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure,nHuntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders,nmyelodysplastic syndrome, uveitis or multiple myeloma. |