| abstract |
The present invention relates to acylamino-substituted heteroaromatic compounds ofnthe formula I,n nin which R 1 , R 2 , R 3 , R 4 and R 5 and X have the meanings indicated in the claims. Thencompounds of formula I are valuable pharmaceutically active compounds which arenuseful in the treatment of various disease states including cardiovascular disordersnsuch as atherosclerosis, thrombosis, coronary artery disease, hypertension andncardiac insufficiency. They upregulate the expression of the enzyme endothelial nitricnoxide (NO) synthase and can be applied in conditions in which an increasednexpression of said enzyme or an increased NO level or the normalization of andecreased NO level is desired. The invention furthermore relates to processes for thenpreparation of compounds of the formula I, their use, in particular as activeningredients in pharmaceuticals, and pharmaceutical preparations comprising them. |