| abstract |
The objects of the present invention is to provide anpreventive method for the progress of neuropsychiatricndisorders, a therapeutic agent for neuropsychiatric disorders,na screening method thereof, and a therapeutic method throughnthe analysis of the mechanisms leading to neuropsychiatricndisorders such as Nasu-Hakola diseases and the like. Thennon-human animal model of oligodendrocytes developmentalndisorders was generated by making the DAP12 gene functionndeficient on its chromosome. The DAP12 knockout mouse developsnmyelination disorders including hypomyelinosis in the brain,nparticularly in the frontal head and the thalamus, furthernleading to neuropsychiatric disorders such as Nasu-Hakolandisease and the like with aging. The screening method for antherapeutic agent, the diagnostic method, and the therapeuticnmethod, wherein the DAP12 knockout mouse developing thesendisorders are used, have been developed. |